One reported no deaths in the 50 participants who had received vitamin D, but two deaths in the 26 participants who received the hospital’s usual COVID-19 treatment. Two studies (in participants with severe COVID-19) provided evidence about deaths from any cause. We do not know whether vitamin D helps to prevent death from COVID-19. The other study did not say anything about their participants’ vitamin D status. Only two studies said that their participants were vitamin D-deficient. They used different timings from each other, from one large dose in one study to several smaller doses over 14 days in another study. The studies gave their participants different doses of vitamin D. All the participants tested positive for COVID-19 with a laboratory test called ‘PCR’, which is currently the most accurate test available. Two studies had participants with severe COVID-19 and one had participants with mild COVID-19 or with no symptoms. One study took place in Brazil, and the other two in Spain. We found three studies with 356 participants. We compared and summarised their results, and rated our confidence in the evidence, based on factors such as study methods and sizes. Vitamin D could be given in any form and in any dose. We searched for studies that assessed the use of vitamin D as a treatment for adults with confirmed COVID-19 compared with a placebo (sham treatment) or another treatment. improvement or worsening of the patient’s condition We wanted to find out the effects of giving vitamin D to adults with confirmed COVID-19 on the following: These are areas affected by COVID-19, so giving vitamin D to people with COVID-19 might help them to recover more quickly or have the disease less severely. It also has a role in boosting the body’s immune system. It helps to regulate blood sugar, the heart and blood vessels, and the lungs and airways. Vitamin D is important for healthy bones, teeth and muscles.
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Risk factors include general ill-health, a poor diet, and pre-existing health conditions, such as diabetes, and liver and kidney disease. However, the risk factors for developing severe COVID-19 are the same as those for developing vitamin D deficiency, so it is difficult to tell if vitamin D deficiency itself is a risk factor for severe COVID-19. Some studies have shown that people who are in hospital with severe COVID-19 also have low levels of vitamin D (vitamin D deficiency). What is the link between vitamin D and COVID-19?
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We will update this review when more evidence becomes available.
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We identified 21 studies on this topic that are ongoing. Future research should focus on well-designed studies with robust methods. We did not find enough, good-quality evidence to judge whether vitamin D is an effective or safe treatment for adults with COVID-19.